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© IRL Press Limited

Nucleic acid and protein sequence databases

G.G. Kneale 1 and M.J. Bishop 2

1Chemical Laboratory, University of Cambridge Lensfield Road, Cambridge CB2 1EW, UK
2Department of Zoology, University of Cambridge Downing Street, Cambridge CB2 3EJ, UK

Nucleic acid and protein sequences contain a wealth of information of interest to molecular biologists. The advent of molecular sequence databases provides a unique opportunity for the computer analysis of all available sequences. Sequence databases serve two main functions: (i) to facilitate comparisons with newly determined sequences, and (ii) to act as a source of data for the generation and testing of hypotheses concerning molecular sequence organisation and evolution. The large amounts of sequence data now becoming available require that algorithms for database searching be fast and efficient and considerable progress is being made in this area.


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