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© Oxford University Press

A Macintosh program for the versatile generation of random nucleic acid sequences and their structural analysis

Frank-Ulrich Gast

Abteilung Viroidforschung, Mar-Planck-Institut für Biochemie, D-82143 Planegg-Martinsried, Germany

The program ‘MacStAn’ for the Apple Macintosh generates random sequences and can analyze their tendency to form secondary structure or translation products as well as their mono-, di- and trinucleotide composition. Generation of random sequences is versatile in that one can (i) predefine the G + C content, maximal base repetitions and constant regions; (ii) preset the entire dinucleotide composition; or (iii) shuffle an existing sequence. The program constitutes an integrated package with a graphical user interface, fill-featured editing, saving, printing, text import and export, dot plot and sequence alignment.

Received on June 10, 1993; accepted on September 10, 1993

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