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© Oxford University Press

Maximum likelihood estimation of quantitative trait loci parameters with the aid of genetic markers using a standard statistical package

Y. Elkind , B. Nir and J.I. Weller 1

Faculty of Agriculture, The Hebrew University Rehovot 76100
1Institute of Animal Sciences, ARO, The Volcam Center Bet Dagan 50250, Israel

Consistent parameter estimates of quantitative trait loci linked to genetic markers can be derived by maximum likelihood methodology. For many experimental designs of interest, parameter estimates and their standard errors can be obtained by program LE of BMDP, which uses the Newton–Raphson method of iteration. Program LE was tested on data simulated for a backcross between two inbred lines. A single quantitative trait locus linked to either one or two genetic markers was simulated. Convergence was rapid, and computing and programming time were insignificant. All parameter estimates were within the expected bounds. Many different designs can be readily analyzed.

Received on May 12, 1994; accepted on June 15, 1994

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