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© Oxford University Press

A consensus procedure for predicting the location of {alpha}-Helical transmembrane segments in proteins

L.A. Parodi , C.A. Granatir and G.M. Maggiora

Computational Chemistry, Upjohn Laboratories Kalamazoo, MI 49008, USA

To aid in the development of three-dimensional models of membrane-bound proteins, a consensus procedure for predicting {alpha}-helical transmembrane segments from amino acid sequences is presented. The algorithm combines the results of six individual prediction methods and some basic properties of membrane-spanning helices to obtain a final concensus prediction. Comparison with experiment and several other recently developed methods shows that the consensus procedure performs quite well in comparison to other recent methods. A FORTRAN program has been developed which takes an input file containing an amino acid sequence in one-letter code and outputs a list of the {alpha}-helical transmembrane segments predicted by the consensus algorithm.


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 Protein Eng Des SelHome page
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