Simulation of aggregation in Dictyostelium using the Cell Programming Language
Coutant Institute of Mathematical Sciences, New York University 251 Mercer Street, New York, NY 10012, USA
In developmental biology, modeling and simulation play an important role in understanding cellular interactions. We suggest a simple language, the Cell Programming Lan guage (CPL), to write computer programs to describe this behavior. Using these programs, it is possible to simulate and visualize intercellular behavior. We employ CPL to model aggregation in Dictyostelium in response to a chemo tactic agent. CPL programs are utilized to model a variety of aggregation behavior including streaming, spiral formation and the effect of amoeba density on aggregation patterns. We believe CPL is a useful tool for developing. understanding and checking biological models that utilize cellular interactions.