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© Oxford University Press

An image-processing approach to dotplots: an X-Window-based program for interactive analysis of dotplots derived from sequence and structural data

Oswaldo Trelles-Salazar 1, Emilio L. Zapata 1, Joaquín Dopazo 2, Andrew F.W. Coulson 3 and José-María Carazo 1,2,4

1Departamento de Arquitectura y Tecnología de Ordenadores, Universidad de Málaga
2Unidad de Biocomputación, Centro Nacional de Biotecnologia, CSIC, Universidad Aulónoma 28049 Madrid, Spain
3Biocomputating Research Unit, ICMB, University of Edinburgh UK

4To who reprint request should be addressed

We present an approach to the study of the relationships between biological sequences and structures applying image analysis methods to dotplots. We introduce a set of analytical tools based on different types of digital image-processing filters that are new within the context of dotplots. We have reformulated some of the usual approaches in dotplot analysis as mathematical operations on images within the framework of mathematical morphology. An X-Window-based implementation of this new approach has been developed and is available by anonymous FTP.

Received on November 22, 1994; revised on February 15, 1995; accepted on April 12, 1995

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