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© Oxford University Press

HTP: a neural network-based method for predicting the topology of helical transmembrane domains in proteins

Piero Fariselli and Rita Casadio 1

Laboratory of Biophysics, Department of Biology, University of Bolongna I-40126 Bologna, Italy

1 To whom correspondence should be addressed. E-mail:g4xbo3b1{at}cine88.cineca.it

In this paper we describe a microcomputer program (HTP) for predicting the location and orientation of {alpha}-helical transmemhrane segments in integral membrane proteins. HTP is a neural network-based tool which gives as output the protein membrane topology based on the statistical propensity of residues to be located in external and internal loops. This method, which uses single protein sequences as input to the network system, correctly predicts the topology of 71 out of 92 membrane proteins of putative membrane orientation, independently of the protein source.

Received on August 22, 1995; revised on October 27, 1995; accepted on October 27, 1995

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