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© Oxford University Press

GEOMETRY: a software package for nucleotide sequence analysis using statistical geometry in sequence space

Igor Kuznetsov 1 and Pavel Morozov

Laboratory of Molecular Evolution, Institute of Cytology and Genetics Prospekt Lavrentieva 10, Novoslbirsk 630090, Russia

1To whom correspondence should be addressed. E-mail: kuznets{at}benpc.bionet.nsk.su

GEOMETRY is a software package for the analysis of nucleotide sequences using the method of statistical geometry in sequence space. The package consists of programs performing estimation of the average geometry of sequence quartets, analysis of positional variability and computer simulation of parallel and tree-like sequence divergence with user-defined parameters. It provides an independent tool for evaluation of the reliability of conventional phylogenetic trees and calthration of the time of sequence divergence. GEOMETRY may be of interest for all scientists engaged in the study of molecular phylogeny. The package is available by anonymous FTP from ftp.bionet.nsk.su, directory /incoming/molevol/geom.exe, and will be available from EMBL file server.

Received on May 2, 1995; revised on April 4, 1996; accepted on April 17, 1996

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