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© Oxford University Press

LITTLE KEVIN: a program for the estimation of protein homology by analysing the amino acid compositions and sequences

J.P. Grillasca 1,3, D. Aubert 1, R. Planells 2, N. Domingo 1 and H. Lafont 1

1 INSERM U130, 18 Avenue Mozart, 13009 Marseille, France
2INSERM U38, Faculté de Médecine 27 Bd Jean Moulin, 13005 Marseille, France

3To whom correspondence should be addressed

We present here a computational method based on the analysis of amino acid composition for performing comparisons between proteins. This user-friendly and reliable test is aimed at rapidly identifying, from data-base subsets, sequences—if necessary, partial sequences—which share similar amino acid compositions to the input composition (deduced from experimental results). Apparent molecular weight (as determined by SDS-PAGE) and artefactual modifications due to the experimental determination of the amino acid composition are taken into account to perform the comparison. This program thus constitutes a useful tool in searching for the probable identification of either nonsequenced proteins or peptides from hydrolysed proteins.

Received on January 2, 1996; accepted on April 23, 1996

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