XDOM, a graphical tool to analyse domain arrangements in any set of protein sequences
1Laboratoire de Biologie Moléculaire des Relations Plantes-Microoorganismes INRA/CNRS, BP27, F-31326 Castanet-Tolosan Cedex, France
2Laboratoire de Génétique Cellulaire INRA/CNRS, BP27, F-31 326 Castanet-Tolosan Cedex, France
1To whom correspondence should be addressed
MOTIVATION:: To extract the maximum possible information from a set of protein sequences, its modular organization must be known and clearly displayed. This is important both for structural and functional analysis.
RESULTS:: This paper presents an algorithm and a graphical interface called XDOM which performs a systematic analysis of the modular organization of any set of protein sequences. The algorithm is an automatic method to identify putative domains from sequence comparisons. The graphical tool displays the proteins as a set of linked boxes. corresponding to its domains. The method has been tested on a family of bacterial proteins and on whole genomes. It is currently applied to the complete SWISS-PROT database to build the PRODOM database.
AVAILABILITY:: XDOM is available free of charge by anonymous ftp. {{ftp://ftp.toulouse.inra.fr/pub/xdom}}. The Pro-Dom database can he consulted at {{http://protein.toulouse.inra.fr/prodom.html}}.
CONTACT:: E-mail: {{mailto:fcorpet{at}toulouse.inra.fr}}
Received on May 6, 1997; revised on June 17, 1997; accepted on June 18, 1997
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