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Bioinformatics, Vol 14, 886-887, Copyright © 1998 by Oxford University Press

ARTICLES

HIV-1 genotypic resistance: automated sequence analysis and interpretation

CP Goujon, VM Schneider, C Jacomet and JC Nicolas
Service de Microbiologie, Institut Federatif Saint Antoine de Recherche sur la Sante, Hopital Rothschild, 33 Bd de Picpus, 75571, Paris, France. goujon@infobiogen.fr

SUMMARY: We present here GRANT ( G enotypic R esistance An alysis T ool), a program that automatically detects resistance-related mutations in HIV-1 protein sequences, and comments on the degree of resistance conferred when possible. This program is easily user-customizable, allowing immediate updates as new resistance mutations are discovered, or use with an organism other than HIV. AVAILABILITY: The package is available free of charge over the internet, either directly from the authors, or by anonymous ftp (ftp. infobiogen.fr/pub/logiciels/mac/biology or windows as appropriate). Versions exist for PPC and 68K Apple Macintosh running MacOS 7.5 or higher. Microsoft Excel 5.0 is required for quality output. A PC version is in progress. CONTACT: goujon@infobiogen.fr
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