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Bioinformatics, Vol 14, 374-375, Copyright © 1998 by Oxford University Press

ARTICLES

POLINA: detection and evaluation of single amino acid substitutions in protein superfamilies

S Levin and BH Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. slevin@aecom.yu.edu

MOTIVATION AND RESULTS: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. AVAILABILITY: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.h tml. CONTACT: slevin@aecom.yu.edu; bsatir@aecom.yu.edu
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