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Bioinformatics, Vol 15, 89-90, Copyright © 1999 by Oxford University Press


ARTICLES

Application of distance geometry to 3D visualization of sequence relationships

M Forster, A Heath and M Afzal
National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Herts. EN6 3QG, UK. mforster@nibsc.ac.uk

SUMMARY: We describe the application of distance geometry methods to the three-dimensional visualization of sequence relationships, with examples for mumps virus SH gene cDNA and prion protein sequences. Sequence-sequence distance measures may be obtained from either a multiple sequence alignment or from sets of pairwise alignments. AVAILABILITY: C/Perl code and HTML/VRML files from http://www.nibsc.ac.uk/dg3dseq/
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