Bioinformatics Vol. 15 no. 12 1999
Pages 1047-1054
© 1999 Oxford University Press
Ontology for immunogenetics: the IMGT-ONTOLOGY
1 Laboratoire d’ImmunoGénétique Moléculaire, LIGM, UPR CNRS 1142, Institut de Génétique Humaine, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
Motivation: IMGT, the international ImMunoGene- Tics database (http://imgt.cines.fr:8104), created by M.-P. Lefranc, is an integrated database specializing in antigen receptors (immunoglobulins and T-cell receptors) and major histocompatibility complex (MHC) of all vertebrate species. IMGT accurate immunogenetics data are based on the standardization of the biological knowledge provided by the ‘ImMunoGeneTics’ IMGT-ONTOLOGY.
The IMGT-ONTOLOGY describes the classification and specification of terms needed for immunogenetics and bioinformatics. IMGT-ONTOLOGY covers four main concepts: ‘IDENTIFICATION’, ‘DESCRIPTION’, ‘CLASSIFICATION’ and ‘OBTENTION’. These concepts allow an extensive and standardized description and characterization of immunoglobulin and T-cell receptor data. The controlled vocabulary and the annotation rules are indispensable to ensure accuracy, consistency and coherence in IMGT. IMGT-ONTOLOGY allows scientists and clinicians to use, for the first time, identical terms with the same meaning in immunogenetics. It provides a semantic repository that will improve interoperability between specialist and generalist databases.
Availability: Controlled vocabulary and annotation rules are described in the IMGT Scientific chart from the IMGT Marie-Paule page at http://imgt.cines.fr:8104
Contact: lefranc{at}ligm.igh.cnrs.fr
Received on March 26, 1999
; revised on June 4, 1999
; accepted on June 11, 1999
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