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Bioinformatics Vol. 16 no. 10 2000
Pages 950-951
© 2000 Oxford University Press

Applications Note

MASIA: recognition of common patterns and properties in multiple aligned protein sequences

H. Zhu 1, C. H. Schein 1 and W. Braun 1,

1 Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX 77555-1157, USA

Received on March 29, 2000 ; revised on May 26, 2000 ; accepted on June 15, 2000

Summary: MASIA is a software tool for pattern recognition in multiple aligned protein sequences. MASIA converts a sequence to a properties matrix that can be scanned in both vertical and horizontal steps. Consistent patterns are recognized based on the statistical significance of their occurrence. Preset macros can be altered on-line to seek any combination of amino acid properties or sequence characteristics. MASIA output can be used directly by our programs to predict the 3D structure of proteins.

Availability: Access MASIA at http://www.scsb.utmb.edu/masia/masia.html.

Contact: werner{at}newton.utmb.edu

To whom correspondence should be addressed.


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