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Bioinformatics Vol. 16 no. 2 2000
Pages 96-100
© 2000 Oxford University Press

Self-organization and competition in the immune response to cancer invasion: a phase-orientated computational model of oncogenesis

Sorinel Adrian Oprisan 1, Aurel Ardelean 2 and Petre T. Frangopol 2

1 ‘Al.I.Cuza’ University, Department of Theoretical Physics, Blvd. Carol I, no. 11, 6600 Iasi, Romania
2 Western University ‘Vasile Goldis’, Department of Biophysics, Blvd. Revolutiei no. 81, 2900 Arad, Romania

Motivation: Recent studies indicate that fractal dimensions can uncover aspects of cellular dynamics prior to pathological manifestation. In this respect we are interested in building a computational model of oncogenesis able to generate patterns with the same fractal dimension spectrum as the in vivo tumor.

Results: A new theoretical model incorporating a systemic view of oncogenesis in a computational model was proposed. The tumor growth is viewed as competition for resources between the two self-organizing subsystems: the neoplastic and the immune. Numerical simulations revealed that tumor escape can be uncovered in some earlier stage of the immune-system–tumor interaction using multifractal measures. The described computational model is able to simulate also the case of immune, surgical, chemical and radiotherapeutical treatment, as well as their effects.

Availability: The software used is available on request from the authors.

Contact: Sorinel Oprisan, University of New Orleans, Department of Psychology, New Orleans, LA 70148, USA. soprisan{at}uno.edu

Received on July 6, 1999 ; revised on September 15, 1999 ; accepted on September 17, 1999

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