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Bioinformatics Vol. 17 no. 11 2001
Pages 1062-1064
© 2001 Oxford University Press

Discovery Note

Nucleosome formation potential of exons, introns, and Alu repeats

Victor G. Levitsky *, Olga A. Podkolodnaya , Nikolay A. Kolchanov and Nikolay L. Podkolodny

Laboratory of Theoretical Genetics, Institute of Cytology & Genetics, 630090, Lavrentiev ave. 10, Novosibirsk, Russia

Received on December 10, 2000 ; revised on April 14, 2001 ; accepted on August 7, 2001

A program for constructing nucleosome formation potential profile was applied for investigation of exons, introns, and repetitive sequences. The program is available at http://wwwmgs.bionet.nsc.ru/mgs/programs/recon/. We have demonstrated that introns and repetitive sequences exhibit higher nucleosome formation potentials than exons. This fact may be explained by functional saturation of exons with genetic code, hindering the localization of efficient nucleosome positioning sites.

Contact: levitsky{at}bionet.nsc.ru

* To whom correspondence should be addressed.


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