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Bioinformatics Vol. 17 no. 12 2001
Pages 1209-1212
© 2001 Oxford University Press

SPiD: a subtilis protein interaction database

Mark Hoebeke 1,*, Hélène Chiapello 1, Philippe Noirot 2 and Philippe Bessières 1

1 UnitéMathématique, Informatique & Génome, INRA CRV, Route de St. Cyr, F-78026 Versailles Cedex, France
2 Laboratoire de Génétique Microbienne, INRA Domaine de Vilvert, F-78352 Jouy en Josas Cedex, France

Received on March 30, 2001 ; revised on June 11, 2001 ; accepted on June 13, 2001

Motivation: Protein–protein interactions are a potential source of valuable clues in determining the functional role of as yet uncharacterized gene products in metabolic pathways. Graph-like structures emerging from the accumulation of interaction data make it difficult to maintain a consistent and global overview by hand. Bioinformatics tools are needed to perform this graph visualization while maintaining a link to the experimental data.

Results: ‘SPiD’ is an online database for exploring networks of interacting proteins in Bacillus subtilis characterized by the two-hybrid system. Graphical displays of interaction networks are created dynamically as users interactively navigate through these networks. Third party applications can interface the database through a Common Object Request Broker Architecture (CORBA) tier.

Availability: SPiD is available through its web site at http://www-mig.versailles.inra.fr/bdsi/SPiD, and through an Interoperable Object Reference (IOR) and its associated Interface Definition Language (IDL).

Contact: hoebeke{at}versailles.inra.fr

* To whom correspondence should be addressed.


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