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Bioinformatics Vol. 17 no. 4 2001
Pages 364-368
© 2001 Oxford University Press

Original Paper

Strategies for the development of a peptide computer

Hubert Hug 1,* and Rainer Schuler 2

1 Universitäts-Kinderklinik Ulm, Prittwitzstrasse 43, D-89075 Ulm, Germany
2 Abteilung Theoretische Informatik, Universität Ulm, D-89069 Ulm, Germany

Received on August 24, 2000 ; revised on November 8, 2000 ; accepted on November 22, 2000

Motivation: We devise a computational model using protein–protein interactions.

Results: Peptide–antibody interactions can be used to perform a large number of small logical operations in parallel. We show for example how a sequence of operations can be used to compare the number of occurrences of an element in two sets and how to estimate the number of occurrences of an element in a set. Similar to DNA-computing, these techniques could in principle be extended to solve instances of NP-complete problems. We give as an example a procedure to solve examples of the satisfiability problem.

Contact: hubert.hug{at}medizin.uni-ulm.de; schuler{at}informatik.uni-ulm.de

* To whom correspondence should be addressed.


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