Bioinformatics Vol. 17 no. 4 2001
Pages 377-378
© 2001 Oxford University Press
Applications Note |
STRAP: editor for STRuctural Alignments of Proteins
Institute of Biochemistry, Charité, Medical Faculty of the Humboldt University, Monbijoustraße 2a, 10117 Berlin, Germany
Received on May 9, 2000
; revised on October 24, 2000
; accepted on November 22, 2000
Summary: STRAP is a comfortable and extensible tool for the
generation and refinement of multiple alignments of protein
sequences. Various sequence ordered input file formats are supported.
These are the SwissProt-,GenBank-, EMBL-, DSSP- PDB-, MSF-, and plain
ASCII text format. The special feature of STRAP is the simple
visualization of spatial distances of
-atoms
within the alignment. Thus structural information can easily be
incorporated into the sequence alignment and can guide the alignment
process in cases of low sequence similarities. Further STRAP is able
to manage huge alignments comprising a lot of sequences. The protein
viewers and modeling programs INSIGHT, RASMOL and WEBMOL are embedded
into STRAP. STRAP is written in Java. The well-documented source code
can be adapted easily to special requirements. STRAP may become the
basis for complex alignment tools in the future.
Availability: The tool is available to academic institutions at http://www.charite.de/bioinf. The source code can be requested via e-mail.
Contact: christoph.gille{at}charite.de
* To whom correspondence should be addressed.
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