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Bioinformatics Vol. 17 no. 5 2001
Pages 398-404
© 2001 Oxford University Press

Construction of DNA restriction maps based on a simplified experiment

J. Blaewicz 1,2,*, P. Formanowicz 1,2, M. Kasprzak 1,2,{dagger}, M. Jaroszewski 1 and W. T. Markiewicz 2

1 Institute of Computing Science, PoznaUniversity of Technology, Piotrowo 3A, 60-965 Pozna, Poland
2 Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Pozna, Poland

Received on May 8, 2000 ; revised on January 15, 2001 ; accepted on January 25, 2001

Motivation: A formulation of a new problem of the restriction map construction based on a simplified digestion experiment and a development of an algorithm for solving both ideal and noisy data cases of the introduced problem.

Results: A simplified partial digest problem and a branch and cut algorithm for finding the solution of the problem.

Contact: blazewic{at}sol.put.poznan.pl

* To whom correspondence should be addressed.

{dagger} Fellowship holder of the Foundation for Polish Sciences.


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