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Bioinformatics Vol. 17 no. 5 2001
Pages 468-478
© 2001 Oxford University Press

BioMolQuest: integrated database-based retrieval of protein structural and functional information

Yury V. Bukhman and Jeffrey Skolnick *

Laboratory of Computational Genomics, Donald Danforth Plant Science Center, 893 N. Warson Rd, St Louis, MO 63141, USA

Received on July 12, 2000 ; revised on November 13, 2000 ; accepted on January 22, 2001

Motivation: Information about a particular protein or protein family is usually distributed among multiple databases and often in more than one entry in each database. Retrieval and organization of this information can be a laborious task. This task is complicated even further by the existence of alternative terms for the same concept.

Results: The PDB, SWISS-PROT, ENZYME, and CATH databases have been imported into a combined relational database, BioMolQuest. A powerful search engine has been built using this database as a back end. The search engine achieves significant improvements in query performance by automatically utilizing cross-references between the legacy databases. The results of the queries are presented in an organized, hierarchical way.

Availability: http://bioinformatics.danforthcenter.org/yury/public/home.html. Unavailable for commercial users.

Contact: skolnick{at}danforthcenter.org

* To whom correspondence should be addressed.


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 Proc. Natl. Acad. Sci. USAHome page
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