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Bioinformatics Vol. 17 no. 6 2001
Pages 551-556
© 2001 Oxford University Press

Prediction of quaternary structure from primary structure

Robert Garian

School of Computational Sciences, George Mason University, USA

Received on May 8, 2000 ; revised on February 5, 2001 ; accepted on February 15, 2001

Motivation: The ‘sequence implies conformation’ principle has been the motivation for the construction of numerous systems of secondary and tertiary structure prediction. Computational experiments have shown that this principle can now be extended to quaternary structure prediction. This work appears to be the first effort to predict quaternary structure properties from sequence.

Results: The software developed to conduct these experiments was the Quaternary Structure Explorer (QSE). Successful rule-based classifiers have been found that can discriminate between the primary sequences of homodimers and non-homodimers.

Availability: The homodimer classifier can be accessed at http://www.mericity.com

Contact: rgar{at}science.gmu.edu


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