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Bioinformatics Vol. 17 no. 7 2001
Pages 581-586
© 2001 Oxford University Press

LDB2000: sequence-based integrated maps of the human genome

Xiayi Ke , William Tapper and Andrew Collins

Human Genetics Research Division, University of Southampton, Duthie Building (Mailpoint 808), Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK

Received on January 5, 2001 ; revised on March 20, 2001 ; accepted on March 23, 2001

Motivation: Integrated maps are useful for gene mapping and establishing the relationship between recombination and sequence. In this paper we describe algorithms and their implementation for constructing sequence-based integrated maps of the human chromosomes, which are presented in LDB2000, a web based resource. Gene mapping efforts are now focussing on linkage disequilibrium mapping and extension of the integrated map to represent the extent of linkage disequilibrium in different genomic regions would further increase the utility of these maps.

Results: Sequence-based integrated maps have been completed for chromosomes 21 and 22. These maps provide locations for genes and polymorphic markers in sequence and on genetic linkage, radiation hybrid and cytogenetic scales. Single nucleotide polymorphisms associated with genes in the maps are also included and their sequence locations indicated. Related locus information, such as aliases and expression information, can be searched on the WWW site.

Availability: http://cedar.genetics.soton.ac.uk/public_html/LDB2000.html

Contact: arc{at}soton.ac.uk


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