Bioinformatics Vol. 17 no. 7 2001
Pages 646-653
© 2001 Oxford University Press
Evaluation of methods for the prediction of membrane spanning regions
1 EMBL-Outstation European Bioinformatics
Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10
1SD, UK
2 School of Biological Sciences, The
University of Manchester, Oxford Road, Manchester M13 9PT, UK
Received on December 15, 2000
; revised on March 13, 2001
; accepted on March 16, 2001
Motivation: A variety of tools are available to predict the topology of transmembrane proteins. To date no independent evaluation of the performance of these tools has been published. A better understanding of the strengths and weaknesses of the different tools would guide both the biologist and the bioinformatician to make better predictions of membrane protein topology.
Results: Here we present an evaluation of the performance of the currently best known and most widely used methods for the prediction of transmembrane regions in proteins. Our results show that TMHMM is currently the best performing transmembrane prediction program.
Contact: moeller{at}ebi.ac.uk; croning{at}ebi.ac.uk; apweiler{at}ebi.ac.uk
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