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Bioinformatics Vol. 18 no. 11 2002
Pages 1534-1537
© 2002 Oxford University Press

Discovery Note

A motif of a microbial starch-binding domain found in human genethonin

Stefan Janecek

Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská cesta 21, SK-84251 Bratislava, Slovakia

Received on February 5, 2002 ; revised on April 3, 2002 ; accepted on April 25, 2002

Summary: The sequence of the starch-binding domain present in 10% of amylolytic enzymes of microbial origin and classified as the carbohydrate-binding module family 20, was identified in the equivalent part of sequence of human genethonin, a skeletal muscle protein of unknown function. The sequence identity between the starch-binding domain from Bacillus sp. strain 1011 cyclodextrin glucanotransferase and the corresponding segment of human genethonin was higher than 28%. The amino acid residues known to be involved in the raw starch binding were found to be conserved in the genethonin sequence. The three-dimensional structure of the genethonin ‘starch-binding domain’ was modelled and its eventual function briefly discussed.

Contact: stefan.janecek{at}savba.sk


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