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Bioinformatics Vol. 18 no. 11 2002
Pages 1542-1543
© 2002 Oxford University Press

Applications Note

GeneCardsTM 2002: towards a complete, object-oriented, human gene compendium

Marilyn Safran 2,*, Irina Solomon 2, Orit Shmueli 1, Michal Lapidot 1, Shai Shen-Orr 3, Avital Adato 1, Uri Ben-Dor 1, Nir Esterman 1, Naomi Rosen 1, Inga Peter 1, Tsviya Olender 1, Vered Chalifa-Caspi 2 and Doron Lancet 1

1 Departments of Molecular Genetics
2 Biological Services (Bioinformatics Unit)
3 Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel

Received on March 26, 2002 ; revised on May 28, 2002 ; accepted on June 6, 2002

Motivation: In the post-genomic era, functional analysis of genes requires a sophisticated interdisciplinary arsenal. Comprehensive resources are challenged to provide consistently improving, state-of-the-art tools.

Results: GeneCards (Rebhan et al., 1998) has made innovative strides: (a) regular updates and enhancements incorporating new genes enriched with sequences, genomic locations, cDNA assemblies, orthologies, medical information, 3D protein structures, gene expression, and focused SNP summaries; (b) restructured software using object-oriented Perl, migration to schema-driven XML, and (c) pilot studies, introducing methods to produce cards for novel and predicted genes.

Availability: Freely available for educational and research purposes by non-profit institutions at http://bioinfo.weizmann.ac.il/cards and academic mirror sites. Commercial usage requires a license.

Contact: marilyn.safran{at}weizmann.ac.il

Supplementary Information: http://bioinfo.weizmann.ac.il/cards/9pageGC2002Bioinformatics.doc; http://bioinfo.weizmann.ac.il/cards/GeneCardByResource.xsd and http://bioinfo.weizmann.ac.il/cards/GeneCardByFunction.xsd.

* To whom correspondence should be addressed.


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