Bioinformatics Vol. 18 no. 11 2002
Pages 1546-1547
© 2002 Oxford University Press
Applications Note |
QuickTree: building huge Neighbour-Joining trees of protein sequences
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Received on April 12, 2002
; revised on May 20, 2002
; accepted on May 24, 2002
Summary: We have written a fast implementation of the popular Neighbor-Joining tree building algorithm. QuickTree allows the reconstruction of phylogenies for very large protein families (including the largest Pfam alignment containing 27000 HIV GP120 glycoprotein sequences) that would be infeasible using other popular methods.
Availability: The source-code for QuickTree, written in ANSI~C, is freely available via the world wide web at http://www.sanger.ac.uk/Software/analysis/quicktree
Contact: klh{at}sanger.ac.uk
* To whom correspondence should be addressed.
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