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Bioinformatics Vol. 18 no. 4 2002
Pages 626-630
© 2002 Oxford University Press

Discovery Note

The SWIB and the MDM2 domains are homologous and share a common fold

Riccardo Bennett-Lovsey , Sarah E. Hart , Hiroki Shirai and Kenji Mizuguchi *

Department of Biochemistry, University of Cambridge, Old Addenbrookes Site, 80 Tennis Court Road, Cambridge CB2 1GA, UK

Received on September 18, 2001 ; revised on November 13, 2001 ; accepted on November 13, 2001

Using a novel algorithm for protein sequence/structure analysis, we propose a probable homology between the SWIB domain (the conserved domain of the 60 kda subunit of the SWIB complex involved in chromatin remodelling) and the p53-binding domain of the MDM2 oncoprotein. The homology suggests that the SWIB domain would adopt a structure similar to that of the MDM2 domain and that these two families of proteins may share a similar functional mechanism.

Contact: kenji{at}cryst.bioc.cam.ac.uk

* To whom correspondance should be addressed.


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