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Bioinformatics Vol. 18 no. 4 2002
Pages 631-633
© 2002 Oxford University Press


Applications Note

CpGProD: identifying CpG islands associated with transcription start sites in large genomic mammalian sequences

Loïc Ponger * and Dominique Mouchiroud

Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558 - UniversitéClaude Bernard, 43, Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France

Received on September 7, 2001 ; revised on October 23, 2001 ; accepted on November 7, 2001

Results: CpGProD is an application for identifying mammalian promoter regions associated with CpG islands in large genomic sequences. Although it is strictly dedicated to this particular promoter class corresponding to {approx}50% of the genes, CpGProD exhibits a higher sensitivity and specificity than other tools used for promoter prediction. Notably, CpGProD uses different parameters according to species (human, mouse) studied. Moreover, CpGProD predicts the promoter orientation on the DNA strand.

Availability: http://pbil.univ-lyon1.fr/software/cpgprod.html

Supplementary information: http://pbil.univ-lyon1.fr/software/cpgprod.html

Contact: ponger{at}biomserv.univ-lyon1.fr

* To whom correspondence should be addressed.


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