Bioinformatics Vol. 18 no. 5 2002
Pages 769-770
© 2002 Oxford University Press
Applications Note |
The Sulfinator: predicting tyrosine sulfation sites in protein sequences
SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
Received on August 29, 2001
; revised on December 3, 2001
; accepted on December 7, 2001
Summary: Protein tyrosine sulfation is an important post-translational modification of proteins that go through the secretory pathway. No clear-cut acceptor motif can be defined that allows the prediction of tyrosine sulfation sites in polypeptide chains. The Sulfinator is a software tool that can be used to predict tyrosine sulfation sites in protein sequences with an overall accuracy of 98%. Four different Hidden Markov Models were constructed, each of them specialized to recognize sulfated tyrosine residues depending on their location within the sequence: near the N-terminus, near the C-terminus, in the center of a window with a size of at least 25 amino acids, as well as in windows containing several tyrosine residues.
Availability: The Sulfinator is accessible at (http://www.expasy.org/tools/sulfinator/).
Supplementary information: Sulfinator documentation is accessible at (http://www.expasy.org/tools/sulfinator/sulfinator-doc.html).
Abbreviations: SWP: SWISS-PROT accession number.
* To whom correspondence should be addressed.
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