Bioinformatics Vol. 18 no. 6 2002
Pages 894-895
© 2002 Oxford University Press
Applications Note |
DMLE+: Bayesian linkage disequilibrium gene mapping
Department of Medical Genetics, University of Alberta, 8–39 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
Received on November 30, 2001
; revised on February 1, 2002
; accepted on February 13, 2002
Summary: The program DMLE+ allows Bayesian inference of the location of a gene carrying a mutation influencing a discrete trait (such as a disease) and/or other parameters of interest (such as mutation age) based on the observed linkage disequilibrium at multiple genetic markers. DMLE+ uses either individual marker genotypes, or haplotypes, integrates over uncertain population allele frequencies, and can incorporate prior information about gene location from an annotated human genome sequence.
Availability: DMLE+ is available in both Windows GUI and portable UNIX command line versions at http://dmle.org
Contact: queries{at}dmle.org brannala{at}ualberta.ca
* To whom correspondence should be addressed.
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