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Bioinformatics Vol. 18 no. 8 2002
Pages 1143-1144
© 2002 Oxford University Press

Applications Note

DiffTool: building, visualizing and querying protein clusters

Farid Chetouani *, Philippe Glaser and Frank Kunst

Laboratoire Génomique des Microorganismes Pathogénes, Institut Pasteur, Département de Biologie Moléculaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France

Received on January 14, 2002 ; revised on February 25, 2002 ; accepted on March 11, 2002

Summary: DiffTool is a resource to build and visualize protein clusters computed from a sequence database. The package provides a clustering tool to construct protein families according to sequence similarities and a web interface to query the corresponding clusters. A subtractive genome analysis tool selects protein families specific for a genome or a group of genomes. For each protein cluster, DiffTool includes access to sequences, coloured multiple alignments and phylogenetic trees.

Availability: A cluster database built from yeast and complete prokaryotic genomes is queryable at http://bioweb.pasteur.fr/seqanal/difftool. All the Perl sources are freely available to non-profit organizations upon request.

Contact: fchetou{at}infobiogen.fr

* To whom correspondence should be addressed.


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