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Bioinformatics Vol. 18 no. 9 2002
Pages 1268
© 2002 Oxford University Press

Applications Note

UniBLAST: a system to filter, cluster, and display BLAST results and assign unique gene annotation

Yan Zhou 1,2,4, Guyang Matthew Huang 1,2,3,4 and Liping Wei 5,2,3,*

1 Institute of Genetics, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, People's Republic of China
2 Hangzhou Genomics Institute—Institute of Bioinformatics of Zhejiang University—Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, People's Republic of China
3 Beijing Genomics Institute—Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, People's Republic of China
4 Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Zhangjiang High Tech Park, Shanghai 201203, People's Republic of China
5 Nexus Genomics, Inc., 229 Polaris Ave., Suite #6, Mountain View, CA 94043, USA

Received on January 28, 2002 ; revised on March 25, 2002 ; accepted on March 28, 2002

Motivation: More and more often, a gene is epitomized by a large number of sequences in GenBank. This high redundancy makes it very difficult to identify a unique best match for a query sequence from its BLAST results. We developed a novel program UniBLAST that filters out uninformative hits, clusters the redundant hits, groups the hits by LocusLink, and graphically displays the results. We also implemented a scoring function in UniBLAST to assign a unique gene name to a query sequence. UniBLAST significantly increases the efficiency of gene annotation.

Availability: The program is available at http://south.genomics.org.cn/software/uniblast/index.html

Contact: uniblast{at}genomics.org.cn wei{at}nexusgenomics.com

* To whom correspondence should be addressed.


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