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Bioinformatics Vol. 18 no. 9 2002
Pages 1276-1277
© 2002 Oxford University Press

Applications Note

PeCoP: automatic determination of persistently conserved positions in protein families

Iddo Friedberg 1,* and Hanah Margalit 1

1 Department of Molecular Genetics and Biotechnology, The Hebrew University—Hadassah Medical School, 91120, Jerusalem, Israel

Received on February 2, 2002 ; revised on March 31, 2002 ; accepted on April 25, 2002

Summary: PeCoP is a WWW-based service which accepts a protein sequence, and reports positions that are conserved in close and distant sequence family members. The collation of family members is performed using iterative PSI-BLAST runs. Examining positional conservation in close and distant family members enables a better selection of positions that may play a role in determining the protein's structure and function.

Availability: http://bioinformatics.org/pecop

Contact: idoerg{at}burnham.org

Supplementary information: http://bioinformatics.org/pecop/about_pecop

* To whom correspondence should be addressed at present address: The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA


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