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Bioinformatics Vol. 18 no. 90002 2002
Pages S64
© 2002 Oxford University Press

Comparative analysis of protein interaction networks

Peer Bork 1

1 European Molecular Biology Laboratory, Heidelberg, Germany

Received on April 18, 2002 ; accepted on June 15, 2002

Recent advances in proteomics and computational biology have lead to a flood of protein interaction data and resulting interaction networks (e.g. (Gavin et al., 2002)). Here I first analyse the status and quality of parts lists (genes and proteins), then comparatively assess large-scale protein interaction data (von Mering et al., 2002) and finally try to identify biological meaningful units (e.g. pathways, cellular processes) within interaction networks that are derived from the conservation of gene neighborhood (Snel et al., 2002). Possible extensions of gene neighborhood analysis to eukaryotes (von Mering and Bork, 2002) will be discussed.


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