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Bioinformatics Vol. 19 no. 1 2003
Pages 161-162
© 2003 Oxford University Press

Applications Note

InterPreTS: protein Interaction Prediction through Tertiary Structure

Patrick Aloy * and Robert B. Russell

EMBL, Meyerhofstrasse, 1, D-69117, Heidelberg, Germany

Received on May 23, 2002 ; revised on July 15, 2002 ; accepted on July 24, 2002

Summary: InterPreTS (Interaction Prediction through Tertiary Structure) is a web-based version of our method for predicting protein–protein interactions (Aloy and Russell, 2002, Proc. Natl Acad. Sci. USA, 99, 5896–5901). Given a pair of query sequences, we first search for homologues in a database of interacting domains (DBID) of known three-dimensional complex structures. Pairs of sequences homologous to a known interacting pair are scored for how well they preserve the atomic contacts at the interaction interface. InterPreTS includes a useful interface for visualising molecular details of any predicted interaction.

Availability: http://www.russell.embl.de/interprets

Contact: aloy{at}embl.de

* To whom correspondence should be addressed.


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