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Bioinformatics Vol. 19 no. 10 2003
Pages 1216-1220
© 2003 Oxford University Press

Discovery Note

Pyranose oxidase identified as a member of the GMC oxidoreductase family

Mario Albrecht * and Thomas Lengauer

Max-Planck-Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrücken, Germany

Received on December 3, 2002 ; revised on January 9, 2003 ; accepted on January 27, 2003

Fungal pyranose oxidase is a flavoenzyme whose preferred substrate among several monosaccharides is D-glucose. After a comprehensive analysis of conserved features in a structure-based multiple sequence alignment of homologous proteins, we could classify this enzyme into the GMC oxidoreductase family. The identified homology also suggests a three-dimensional protein structure similar to the functionally related glucose oxidase.

Contact: mario.albrecht{at}mpi-sb.mpg.de

* To whom correspondence should be addressed.


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