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Bioinformatics Vol. 19 no. 11 2003
Pages 1368-1370
© 2003 Oxford University Press

Exact significance levels for the maximum {chi}2 method of detecting recombination

M. Spencer

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England

Received on September 30, 2002 ; revised on November 28, 2002 ; accepted on January 20, 2003

Summary:Maynard Smith’s maximum {chi}2 method is a useful tool for detecting recombination. Significance testing is usually carried out by random permutation, which may require a large amount of computer time. I describe an exact algorithm.

Availability: Matlab source code from http://www.bioc.cam.ac.uk/UTOs/howe/

Contact: ms379{at}cam.ac.uk


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