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Bioinformatics Vol. 19 no. 12 2003
Pages 1592-1593
© 2003 Oxford University Press

Applications Note

QAlign: quality-based multiple alignments with dynamic phylogenetic analysis

M. Sammeth 1,2,3,*,{dagger}, J. Rothgänger 4, W. Esser 1, J. Albert 1, J. Stoye 3 and D. Harmsen 5

1 Department of Computer Science II, University of Würzburg, 97074 Würzburg, Germany
2 International Graduate School of Bioinformatics, Bielefeld University, 33594 Bielefeld, Germany
3 Genome Informatics, Department of Technology, Bielefeld University, 33594 Bielefeld, Germany
4 RIDOM bioinformatics, 97082 Würzburg, Germany
5 Institute for Hygiene, University of Münster, 48149 Münster, Germany

Received on December 11, 2002 ; revised on February 12, 2003 ; accepted on March 4, 2003

Summary: Integrating different alignment strategies, a layout editor and tools deriving phylogenetic trees in a ‘multiple alignment environment’ helps to investigate and enhance results of multiple sequence alignment by hand. QAlign combines algorithms for fast progressive and accurate simultaneous multiple alignment with a versatile editor and a dynamic phylogenetic analysis in a convenient graphical user interface.

Availability: QAlign is freely available over the internet at http://www.ridom.de/qalign/. The platform-independent JAVA technology used provides distributions for various operating systems and hardware architectures.

Contact: qalign{at}ridom.de

* To whom correspondence should be addressed.

{dagger} Present address: Genome Informatics, Department of Technology, Bielefeld University, 33594 Bielefeld, Germany.


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