Skip Navigation

This Article
Right arrow FREE Full Text (Print PDF) Freely available
Right arrow FREE Full Text (Screen PDF)
Right arrow Comments: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Comments are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Dombkowski, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dombkowski, A. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Bioinformatics Vol. 19 no. 14 2003
Pages 1852-1853
© 2003 Oxford University Press

Applications Note

Disulfide by DesignTM: a computational method for the rational design of disulfide bonds in proteins

Alan A. Dombkowski

Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA

Received on December 4, 2002 ; revised on March 28, 2003 ; accepted on April 1, 2003

Summary: Disulfide by Design is a program for the design of novel disulfide bonds in proteins. Protein structure files in PDB format are analyzed to identify residue pairs that are likely to form a disulfide bond if the respective amino acids are mutated to cysteines. The output displays residue pairs having the appropriate geometric characteristics for disulfide formation and provides automated generation of modified PDB files including modeled disulfides. Validation demonstrates a high level of accuracy for the algorithm.

Availability: http://www.ehscenter.org/dbd/

Supplementary information: http://www.ehscenter.org/dbd/

Contact: domski{at}wayne.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
H. Zhang, C. Kenaan, D. Hamdane, G. H. B. Hoa, and P. F. Hollenberg
Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1
J. Biol. Chem., September 18, 2009; 284(38): 25678 - 25686.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Mateo, E. Luna, V. Rincon, and M. G. Mateu
Engineering Viable Foot-and-Mouth Disease Viruses with Increased Thermostability as a Step in the Development of Improved Vaccines
J. Virol., December 15, 2008; 82(24): 12232 - 12240.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Guo, J. E. Jureller, J. T. Warren, E. Solomaha, J. Florian, and W.-J. Tang
Protein-Protein Docking and Analysis Reveal That Two Homologous Bacterial Adenylyl Cyclase Toxins Interact with Calmodulin Differently
J. Biol. Chem., August 29, 2008; 283(35): 23836 - 23845.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.