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Bioinformatics Vol. 19 no. 16 2003
pages 2144-2146
© 2003 Oxford University Press

Applications Note

MetaFluxNet: the management of metabolic reaction information and quantitative metabolic flux analysis

Dong-Yup Lee 1,2, Hongsoek Yun 2, Sunwon Park 2 and Sang Yup Lee 1,2,3,*

1 Metabolic and Biomolecular Engineering National Research Laboratory, 2 Department of Chemical and Biomolecular Engineering, and BioProcess Engineering Research Center and 3 Department of BioSystems and Bioinformatics Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Korea

Received on January 13, 2003 ; revised on April 24, 2003 ; accepted on May 9, 2003

Summary: MetaFluxNet is a program package for managing information on the metabolic reaction network and for quantitatively analyzing metabolic fluxes in an interactive and customized way. It allows users to interpret and examine metabolic behavior in response to genetic and/or environmental modifications. As a result, quantitative in silico simulations of metabolic pathways can be carried out to understand the metabolic status and to design the metabolic engineering strategies. The main features of the program include a well-developed model construction environment, user-friendly interface for metabolic flux analysis (MFA), comparative MFA of strains having different genotypes under various environmental conditions, and automated pathway layout creation.

Availability: http://mbel.kaist.ac.kr/

Supplementary information: A manual for MetaFluxNet is available as PDF file.

Contact: leesy{at}kaist.ac.kr

* To whom correspondence should be addressed.


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