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Bioinformatics Vol. 19 no. 17 2003
pages 2176-2190
© 2003 Oxford University Press

Review

Early bioinformatics: the birth of a discipline—a personal view

Christos A. Ouzounis 1,* and Alfonso Valencia 2

1 Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK, 2 Protein Design Group, National Center for Biotechnology, CNB-CSIC Campus U. Autonoma Cantoblanco, Madrid 28049, Spain

Received on December 13, 2002 ; revised on May 25, 2003 ; accepted on March 28, 2003

Motivation: The field of bioinformatics has experienced an explosive growth in the last decade, yet this ‘new’ field has a long history. Some historical perspectives have been previously provided by the founders of this field. Here, we take the opportunity to review the early stages and follow developments of this discipline from a personal perspective.

Results: We review the early days of algorithmic questions and answers in biology, the theoretical foundations of bioinformatics, the development of algorithms and database resources and finally provide a realistic picture of what the field looked like from a resources and finally provide a realistic picture of what the field looked like from a practitioner's viewpoint 10 years ago, with a perspective for future developments.

Contact: ouzounis{at}ebi.ac.uk

* To whom correspondence should be addressed.


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