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Bioinformatics Vol. 19 no. 2 2003
Pages 256-260
© 2003 Oxford University Press

Fractional populations in multiple gene inheritance

Myung-Hoon Chung 1,2,*, Chul Koo Kim 3,4 and Kyun Nahm 5

1 Department of Physics, Hong-Ik University, Chochiwon, Choongnam 339-800, Korea
2 Department of Physics, Yale University, New Haven, CT 06520, USA
3 Institute of Physics and Applied Physics, Yonsei University, Seoul 120-749, Korea
4 Center for Strongly Correlated Materials Research, Seoul National University, Seoul 151-742, Korea
5 Department of Physics, Yonsei University, Wonju 220-710, Korea

Received on April 30, 2002 ; revised on August 8, 2002 ; accepted on August 13, 2002

Motivation: With complete knowledge of the human genome sequence, one of the most interesting tasks remaining is to understand the functions of individual genes and how they communicate. Using the information about genes (locus, allele, mutation rate, fitness, etc.), we attempt to explain population demographic data. This population evolution study could complement and enhance biologists’ understanding about genes.

Results: We present a general approach to study population genetics in complex situations. In the present approach, multiple allele inheritance, multiple loci inheritance, natural selection and mutations are allowed simultaneously in order to consider a more realistic situation. A simulation program is presented so that readers can readily carry out studies with their own parameters. It is shown that the multiplicity of the loci greatly affects the demographic results of fractional population ratios. Furthermore, the study indicates that some high infant mortality rates due to congenital anomalies can be attributed to multiple loci inheritance.

Availability: The simulation program can be downloaded from http://won.hongik.ac.kr/~mhchung/index_files/yapop.htm. In order to run this program, one needs Visual Studio .NET platform, which can be downloaded from http://msdn.microsoft.com/netframework/downloads/default.asp.

Contact: mhchung{at}hongik.ac.kr

* To whom correspondence should be addressed.


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