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Bioinformatics Vol. 19 no. 3 2003
Pages 336-344
© 2003 Oxford University Press

JOBIM Paper

Genetic Network Analyzer: qualitative simulation of genetic regulatory networks

Hidde de Jong 1,*, Johannes Geiselmann 2, Céline Hernandez 1 and Michel Page 1,3

1 INRIA Rhône-Alpes, 655 avenue de l’Europe, Montbonnot, 38334 Saint Ismier CEDEX, France
2 PEGM, Université Joseph Fourier, Grenoble
3 ESA, Université Pierre Mendès France, Grenoble

Received on February 1, 2002 ; revised on June 5, 2002 ; accepted on August 12, 2002

Motivation: The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes.

Results: We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis.

Availability: GNA and the model of the sporulation network are available at http://www-helix.inrialpes.fr/gna

Contact: Hidde.de-Jong{at}inrialpes.fr

* To whom correspondence should be addressed.


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