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Bioinformatics Vol. 19 no. 5 2003
Pages 667-668
© 2003 Oxford University Press

Applications Note

GPCR-GRAPA-LIB—a refined library of hidden Markov Models for annotating GPCRs

Ron Shigeta *, Melissa Cline , Guoying Liu and Michael A. Siani-Rose

Affymetrix Corporation, Bioinformatics, 6550 Vallejo Street, Suite 100 Emeryville, CA 94608, USA

Received on June 13, 2002 ; revised on October 14, 2002 ; accepted on November 22, 2002

Summary: GPCR-GRAPA-LIB is a library of HMMs describing G protein coupled receptor families. These families are initially defined by class of receptor ligand, with divergent families divided into subfamilies using phylogenic analysis and knowledge of GPCR function. Protein sequences are applied to the models with the GRAPA curve-based selection criteria. RefSeq sequences for Homo sapiens, Drosophila melanogaster, and Caenorhabditis elegans have been annotated using this approach.

Availability: The HMMs and sequence alignments are available at http://www.affymetrix.com/community/publications/affymetrix/index.affx. Annotation results are available at http://www.affymetrix.com/analysis/index.affx

Contact: ron_shigeta{at}affymetrix.com

* To whom correspondence should be addressed.


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