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Bioinformatics Vol. 19 no. 6 2003
Pages 782-783
© 2003 Oxford University Press

Applications Note

Phylogenetic Web Profiler

Philip Wong 1, Grigory Kolesov 2, Dmitrij Frishman 2 and Walid A. Houry 1,*

1 Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada
2 Institute for Bioinformatics, Ingolstädter Landstrasse 1, GSF—National Research Center for Environment and Health, 85764 Neuherberg, Germany

Received on September 27, 2002 ; revised on November 25, 2002 ; accepted on December 10, 2002

Summary: Phylogenetic Web Profiler (PWP) is a web-based service designed to perform phylogenetic profiling of proteins against genomes. The current version offers a selection of 63 completed genomes and available plasmids as annotated in the PEDANT genome database. Unlike currently available applications, this tool offers several choices of ortholog prediction parameters including E-value cutoff, percent length difference tolerance, and annotation similarity. Additional features include tight integration with the PEDANT database and tools to analyze properties of predicted proteins. PWP should prove very useful for the analysis of functional-linkage between proteins.

Availability: The PWP server is available at http://pedant.gsf.de/pwp/. The PWP functional predictions are also offered as part of the PEDANT genome analysis server (http://pedant.gsf.de).

Contact: walid.houry{at}utoronto.ca

* To whom correspondence should be addressed.


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