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Bioinformatics Vol. 19 no. 7 2003
Pages 895-896
© 2003 Oxford University Press

Applications Note

Do current sequence analysis algorithms disclose multifunctional (moonlighting) proteins?

Antonio Gómez 1,*, Nuria Domedel 1,*, Juan Cedano 1, Jaume Piñol 1 and Enrique Querol 1,{dagger}

1 Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona. 08193 Bellaterra, Barcelona, Spain

Received on September 5, 2002 ; revised on November 12, 2002 and January 9, 2003 ; accepted on January 14, 2003

Sumary: A number of multifunctional, ‘moonlighting’, proteins have been analyzed by different current programs to test wheter they identify both functions. PSI-BLAST and PRODOM perform best in predicting the alternative function.

Contact: enric.querol{at}uab.es

Supplementary information: Full tables and additional information available at http://ibb.uab.es/moonlighting

* The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.

{dagger} To whom correspondence should be addressed.


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