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© 1986 IRL Press Ltd.

A discrete model of bacterial metabolism

M R Watson

Department of Biology and Biochemistry, North East London Polytechnic London E15 4LZ, UK

This paper describes a computer model of the intermediary metabolism of bacteria during steady-state growth and during adaptations, e g. to new carbon sources. Metabolic regulation is represented as a process of optimisation, in which the trend is towards improved metabolic performance. The model uses linear programming techniques for the optimisation The implementation falls into four phases: (i) assembly of model parameters; (ii) calculations; (iii) storage of solutions and (iv) projection of solutions. The use of a commercial database and a commercial spreadsheet has proved to be of great assistance in the first and third phases. A metabolic map format, with the optional addition of conversion values, names of enzymes or co-factors has been used to project the results in a form convenient for inspection.

Received on August 22, 1985; accepted on January 3, 1985

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