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© IRL Press Limited

A microcomputer program for hydropathic analysis of proteins with I/O through word processing and graphics software

Michael J. Weise *

Department of Neurology and The Program for Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina Charleston, SC 29425, USA

*To whom reprint requests should be sent at Department of Neurology, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425, USA

A BASIC program has been devised for the hydropathic analysis of protein sequences according to the method of Kyte and Doolittle (1982). The program uses sequence data from input files that are created with a word processor and produces two types of output file: one contains a bar graph of the hydropathic profile in a format that can be easily edited; the other is a tabulation of hydropathic indices along a protein's sequence that can be used as input by the program for the production of a bar graph or as input into other graphics and analysis software. An MS-DOS microcomputer, operating under IBM BASICA or GWBASIC and a dot matrix printer with block graphics capabilities are the only hardware requirements for graphic display of hydropathy profiles. The program is capable of unattended analysis from a list of up to 15 input files.

; accepted on March 10, 1986

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